토토 사이트 먹튀ICS/BK21 SEMINAR[09.10.28]
관련링크
본문
"
Toward an Unified Description for Thermodynamics,
Folding Kinetics, and Mutagenesis of Proteins”
* Speaker : Prof. Ik Soo Chang[Pusan National University]
* Place : 올림픽 토토 Seminar Room (Science Bldg, 3-201)
* Date & Time : Oct,올림픽 토토16Fri)올림픽 토토4:00 ~ 5:00 pm
Abstract
A multiscale-heterogeneous protein energy function was developed for the biophysical study of the
thermodynamics, folding kinetics, and mutagenesis of proteins. After hybridizing an올림픽 토토atomic올림픽 토토force-
field into a coarse-grained energy function to account for the specificity of a올림픽 토토sequence올림픽 토토of올림픽 토토amino
acids even with the high structural homology, we constructed an exact free energy landscape of a
given protein and characterized its thermodynamics and folding-unfolding kinetics via올림픽 토토a올림픽 토토Chevron
plot based on solving exactly a master equation, which would enable us to pursue올림픽 토토a올림픽 토토mutagenesis
application. Our approach was applied successfully for resolving a controversy올림픽 토토about올림픽 토토the올림픽 토토folding
mechanism of fast folding proteins.
Recent experiments claiming that BBL protein follows a global downhill folding raised an important
controversy as to the folding mechanism of fast folding proteins. Under the global downhill folding
scenario not only proteins undergo a gradual folding, but also folding events along the continuous
folding pathway could be mapped out from the equilibrium denaturation experiment. Based on the
exact calculation using a free energy landscape, relaxation eigenmodes from올림픽 토토a올림픽 토토master올림픽 토토equation,
and Monte Carlo simulation of an올림픽 토토extended올림픽 토토Munoz-Eaton올림픽 토토model올림픽 토토that올림픽 토토incorporates올림픽 토토multiscale-
heterogeneous pairwise-interactions between amino acids, here we show that the very nature of a
two-state cooperative transition such as a bimodal distribution from an exact free energy landscape
and biphasic relaxation kinetics do manifest in the thermodynamics올림픽 토토and올림픽 토토folding-unfolding올림픽 토토kinetics
of BBL and peripheral subunit-binding domain (PSBD) homologue. Our results provide an unequivocal
resolution to the fundamental controversy related to올림픽 토토the올림픽 토토global올림픽 토토downhill올림픽 토토folding올림픽 토토scheme,올림픽 토토whose
applicability to other proteins should be critically re-examined.
Contact Person : Prof. Ki Bong Lee (054-279-2068, kibong@postech.ac.kr)
"
Toward an Unified Description for Thermodynamics,
Folding Kinetics, and Mutagenesis of Proteins”
* Speaker : Prof. Ik Soo Chang[Pusan National University]
* Place : 올림픽 토토 Seminar Room (Science Bldg, 3-201)
* Date & Time : Oct,올림픽 토토16Fri)올림픽 토토4:00 ~ 5:00 pm
Abstract
A multiscale-heterogeneous protein energy function was developed for the biophysical study of the
thermodynamics, folding kinetics, and mutagenesis of proteins. After hybridizing an올림픽 토토atomic올림픽 토토force-
field into a coarse-grained energy function to account for the specificity of a올림픽 토토sequence올림픽 토토of올림픽 토토amino
acids even with the high structural homology, we constructed an exact free energy landscape of a
given protein and characterized its thermodynamics and folding-unfolding kinetics via올림픽 토토a올림픽 토토Chevron
plot based on solving exactly a master equation, which would enable us to pursue올림픽 토토a올림픽 토토mutagenesis
application. Our approach was applied successfully for resolving a controversy올림픽 토토about올림픽 토토the올림픽 토토folding
mechanism of fast folding proteins.
Recent experiments claiming that BBL protein follows a global downhill folding raised an important
controversy as to the folding mechanism of fast folding proteins. Under the global downhill folding
scenario not only proteins undergo a gradual folding, but also folding events along the continuous
folding pathway could be mapped out from the equilibrium denaturation experiment. Based on the
exact calculation using a free energy landscape, relaxation eigenmodes from올림픽 토토a올림픽 토토master올림픽 토토equation,
and Monte Carlo simulation of an올림픽 토토extended올림픽 토토Munoz-Eaton올림픽 토토model올림픽 토토that올림픽 토토incorporates올림픽 토토multiscale-
heterogeneous pairwise-interactions between amino acids, here we show that the very nature of a
two-state cooperative transition such as a bimodal distribution from an exact free energy landscape
and biphasic relaxation kinetics do manifest in the thermodynamics올림픽 토토and올림픽 토토folding-unfolding올림픽 토토kinetics
of BBL and peripheral subunit-binding domain (PSBD) homologue. Our results provide an unequivocal
resolution to the fundamental controversy related to올림픽 토토the올림픽 토토global올림픽 토토downhill올림픽 토토folding올림픽 토토scheme,올림픽 토토whose
applicability to other proteins should be critically re-examined.
Contact Person : Prof. Ki Bong Lee (054-279-2068, kibong@postech.ac.kr)
"
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