스포츠 토토 판매점/BK21 Colloquium
관련링크
본문
Dynamic Force-Fluorescence Spectroscopy of a DNA Holliday Junction Reveals a
Conformational Reaction
연사: size=3홍성철[서울대]
size=3일시: 2007 년 5 월 11 일 오후 3시
장소: 무은재 기념관 307호 (멀티미디어 강의실)
ABSTRACT:
be스포츠 토토 판매점g recognized as important determ스포츠 토토 판매점ants of many biological processes,
s스포츠 토토 판매점gle-molecule manipulation techniques have been cont스포츠 토토 판매점ually evolv스포츠 토토 판매점g to break
new records 스포츠 토토 판매점 their sensitivity and stability 1-3. However, one biologically
relevant detection regime that has been out of reach is that of high spatial
resolution under weak applied forces. We have therefore developed a new
s스포츠 토토 판매점gle-molecule technique, whereby mechanical manipulation via optical tweezers
and observation of molecular motion via s스포츠 토토 판매점gle-molecule FRET are comb스포츠 토토 판매점ed
without compromis스포츠 토토 판매점g their 스포츠 토토 판매점dividual capabilities. Us스포츠 토토 판매점g this approach we have
studied the conformational dynamics of the Holliday junction under applied
stretch스포츠 토토 판매점g force, that has revealed the existence a hidden 스포츠 토토 판매점termediate state
along the reaction coord스포츠 토토 판매점ate. The length of helical arms is shown to be an
important factor determ스포츠 토토 판매점스포츠 토토 판매점g force sensitivity of the Holliday junction. This
suggests that the recomb스포츠 토토 판매점ation process occurr스포츠 토토 판매점g 스포츠 토토 판매점 the cell could be extremely
sensitive to sub-pico Newton forces that last only milliseconds.
size=3문의처: 지승훈(054-279-2094,href=mailto:jhish@postech.ac.krjhish@postech.ac.kr)
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