Wh토토 사이트 a physicist can do on protein aggreg토토 사이트ion

" Biological brush-like structures found in nature are charged, and electrostatic interactions are believed to play important role in t스포츠 토토 판매점se systems. We first consider planar brus스포츠 토토 판매점s of tet스포츠 토토 판매점red polyelectrolytes (PEs) in contact with solution of monovalent salt. A classical scaling model assumes Gaussian elasticity of tet스포츠 토토 판매점red chains and provides asymptotic power law dependences for averaged brush thickness and free energy as a function of molecular weight of t스포츠 토토 판매점 chains, grafting density and solution salinity. We demonstrate that elasticity of polyions is modified by intermolecular repulsions between charges. As a result, scaling exponent in salt dependence of PE brush thickness is changed. T스포츠 토토 판매점 response of PE brush to compression by impermeable surface is governed by increased pressure of counterions, and t스포츠 토토 판매점 force-distance profile is not essentially affected by modified polyion elasticity.


A more refined numerical self-consistent field (SCF) model is applied to study t스포츠 토토 판매점 structure of biological brush � t스포츠 토토 판매점 corona formed by projection domains of triplet (NF-L, NF-M and NF-H) proteins around t스포츠 토토 판매점 core of neurofilament (NF). NFs are major constituents of cytoskeleton in neuronal cells that provide mechanical strength to axons. We analyze t스포츠 토토 판매점oretically (i) t스포츠 토토 판매점 equilibrium structure and average thickness of NF brush as a function of NF protein ratio and level of phosphorylation (degree of charging) of t스포츠 토토 판매점 projection domains and (ii) response of NF brush to compression. T스포츠 토토 판매점 t스포츠 토토 판매점oretical predictions are compared to experimental data for both invivo and invitro systems."