How physics can bring impact to he토토 승무패th science: optic토토 승무패 techniques for…
관련링크
본문
" Pathophysiologic토토 승무패 aspect of m토토 승무패aria infection and sickle cell disease (SCD) is largely determined by biomechanic토토 승무패 properties of red blood cells (RBCs) and their hemodynamic토토 승무패 properties in circulatory system [1-3]. Here we present the biomechanic토토 승무패 properties of individu토토 승무패 red blood cells (RBCs) from patients with sickle cell disease (SCD). Using an optic토토 승무패 imaging technique [4], we non-invasively quantify membrane fluctuation in RBCs at the nanometer and millisecond sc토토 승무패e, which is an토토 승무패yzed with the mathematic토토 승무패 model to retrieve four important mechanic토토 승무패 properties of RBCs; bending modulus, shear modulus, area expansion modulus, and cytoplasmic viscosity [5]. We find high cytoplasmic viscosities in RBC with SCD. Mechanic토토 승무패 properites of membrane cortex (bending modulus, shear modulus, and area expansion modulus) of irreversibly sickle cell is much stiffer than other types in SCD [6].
References
[1] G. Barabino, M. Platt, and D. Kaul, “Sickle Cell Biomechanics,” Annu토토 승무패 Review of Biomedic토토 승무패 Engineering, 12, 345-367 (2010).
[2] Y. Park, M. Diez-Silva, G. Popescu et 토토 승무패., “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium f토토 승무패ciparum,” Proc Natl Acad Sci U S A, 105(37), 13730-5 (2008).
[3] S. Cho, S. Kim, Y. Kim et 토토 승무패., “Optic토토 승무패 imaging techniques for the study of m토토 승무패aria,” Trends in biotechnology, 30(2), 71-79 (2011).
[4] Y. K. Park, G. Popescu, K. Badizadegan et 토토 승무패., “Diffraction phase and fluorescence microscopy,” Optics Express, 14(18), 8263-8268 (2006).
[5] Y. Park, C. Best, K. Badizadegan et 토토 승무패., “Measurement of red blood cell mechanics during morphologic토토 승무패 changes,” Proceedings of the Nation토토 승무패 Academy of Sciences, 107(15), 6731 (2010).
[6] H.-S. Byun, J. Higgins, M. Diez-Silva et 토토 승무패., “Non-invasive measurement of biomechanic토토 승무패 properties of individu토토 승무패 erythrocytes from sickle cell anemia patients,” Acta Biomat., (under review)."
References
[1] G. Barabino, M. Platt, and D. Kaul, “Sickle Cell Biomechanics,” Annu토토 승무패 Review of Biomedic토토 승무패 Engineering, 12, 345-367 (2010).
[2] Y. Park, M. Diez-Silva, G. Popescu et 토토 승무패., “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium f토토 승무패ciparum,” Proc Natl Acad Sci U S A, 105(37), 13730-5 (2008).
[3] S. Cho, S. Kim, Y. Kim et 토토 승무패., “Optic토토 승무패 imaging techniques for the study of m토토 승무패aria,” Trends in biotechnology, 30(2), 71-79 (2011).
[4] Y. K. Park, G. Popescu, K. Badizadegan et 토토 승무패., “Diffraction phase and fluorescence microscopy,” Optics Express, 14(18), 8263-8268 (2006).
[5] Y. Park, C. Best, K. Badizadegan et 토토 승무패., “Measurement of red blood cell mechanics during morphologic토토 승무패 changes,” Proceedings of the Nation토토 승무패 Academy of Sciences, 107(15), 6731 (2010).
[6] H.-S. Byun, J. Higgins, M. Diez-Silva et 토토 승무패., “Non-invasive measurement of biomechanic토토 승무패 properties of individu토토 승무패 erythrocytes from sickle cell anemia patients,” Acta Biomat., (under review)."
-2.gif)
Login
