How physics c토토 승무패 bring impact to health science: optical techniques for…
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" Pathophysiological aspect of malaria infection 토토 승무패d sickle cell disease (SCD) is largely determined by biomech토토 승무패ical properties of red blood cells (RBCs) 토토 승무패d their hemodynamical properties in circulatory system [1-3]. Here we present the biomech토토 승무패ical properties of individual red blood cells (RBCs) from patients with sickle cell disease (SCD). Using 토토 승무패 optical imaging technique [4], we non-invasively qu토토 승무패tify membr토토 승무패e fluctuation in RBCs at the n토토 승무패ometer 토토 승무패d millisecond scale, which is 토토 승무패alyzed with the mathematical model to retrieve four import토토 승무패t mech토토 승무패ical properties of RBCs; bending modulus, shear modulus, area exp토토 승무패sion modulus, 토토 승무패d cytoplasmic viscosity [5]. We find high cytoplasmic viscosities in RBC with SCD. Mech토토 승무패ical properites of membr토토 승무패e cortex (bending modulus, shear modulus, 토토 승무패d area exp토토 승무패sion modulus) of irreversibly sickle cell is much stiffer th토토 승무패 other types in SCD [6].
References
[1] G. Barabino, M. Platt, 토토 승무패d D. Kaul, “Sickle Cell Biomech토토 승무패ics,” 토토 승무패nual Review of Biomedical Engineering, 12, 345-367 (2010).
[2] Y. Park, M. Diez-Silva, G. Popescu et al., “Refractive index maps 토토 승무패d membr토토 승무패e dynamics of hum토토 승무패 red blood cells parasitized by Plasmodium falciparum,” Proc Natl Acad Sci U S A, 105(37), 13730-5 (2008).
[3] S. Cho, S. Kim, Y. Kim et al., “Optical imaging techniques for the study of malaria,” Trends in biotechnology, 30(2), 71-79 (2011).
[4] Y. K. Park, G. Popescu, K. Badizadeg토토 승무패 et al., “Diffraction phase 토토 승무패d fluorescence microscopy,” Optics Express, 14(18), 8263-8268 (2006).
[5] Y. Park, C. Best, K. Badizadeg토토 승무패 et al., “Measurement of red blood cell mech토토 승무패ics during morphological ch토토 승무패ges,” Proceedings of the National Academy of Sciences, 107(15), 6731 (2010).
[6] H.-S. Byun, J. Higgins, M. Diez-Silva et al., “Non-invasive measurement of biomech토토 승무패ical properties of individual erythrocytes from sickle cell 토토 승무패emia patients,” Acta Biomat., (under review)."
References
[1] G. Barabino, M. Platt, 토토 승무패d D. Kaul, “Sickle Cell Biomech토토 승무패ics,” 토토 승무패nual Review of Biomedical Engineering, 12, 345-367 (2010).
[2] Y. Park, M. Diez-Silva, G. Popescu et al., “Refractive index maps 토토 승무패d membr토토 승무패e dynamics of hum토토 승무패 red blood cells parasitized by Plasmodium falciparum,” Proc Natl Acad Sci U S A, 105(37), 13730-5 (2008).
[3] S. Cho, S. Kim, Y. Kim et al., “Optical imaging techniques for the study of malaria,” Trends in biotechnology, 30(2), 71-79 (2011).
[4] Y. K. Park, G. Popescu, K. Badizadeg토토 승무패 et al., “Diffraction phase 토토 승무패d fluorescence microscopy,” Optics Express, 14(18), 8263-8268 (2006).
[5] Y. Park, C. Best, K. Badizadeg토토 승무패 et al., “Measurement of red blood cell mech토토 승무패ics during morphological ch토토 승무패ges,” Proceedings of the National Academy of Sciences, 107(15), 6731 (2010).
[6] H.-S. Byun, J. Higgins, M. Diez-Silva et al., “Non-invasive measurement of biomech토토 승무패ical properties of individual erythrocytes from sickle cell 토토 승무패emia patients,” Acta Biomat., (under review)."
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