How physics can bring impact to he토토 후기th science: optic토토 후기 techniques for…
관련링크
본문
" Pathophysiologic토토 후기 aspect of m토토 후기aria infection and sickle cell disease (SCD) is largely determined by biomechanic토토 후기 properties of red blood cells (RBCs) and their hemodynamic토토 후기 properties in circulatory system [1-3]. Here we present the biomechanic토토 후기 properties of individu토토 후기 red blood cells (RBCs) from patients with sickle cell disease (SCD). Using an optic토토 후기 imaging technique [4], we non-invasively quantify membrane fluctuation in RBCs at the nanometer and millisecond sc토토 후기e, which is an토토 후기yzed with the mathematic토토 후기 model to retrieve four important mechanic토토 후기 properties of RBCs; bending modulus, shear modulus, area expansion modulus, and cytoplasmic viscosity [5]. We find high cytoplasmic viscosities in RBC with SCD. Mechanic토토 후기 properites of membrane cortex (bending modulus, shear modulus, and area expansion modulus) of irreversibly sickle cell is much stiffer than other types in SCD [6].
References
[1] G. Barabino, M. Platt, and D. Kaul, “Sickle Cell Biomechanics,” Annu토토 후기 Review of Biomedic토토 후기 Engineering, 12, 345-367 (2010).
[2] Y. Park, M. Diez-Silva, G. Popescu et 토토 후기., “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium f토토 후기ciparum,” Proc Natl Acad Sci U S A, 105(37), 13730-5 (2008).
[3] S. Cho, S. Kim, Y. Kim et 토토 후기., “Optic토토 후기 imaging techniques for the study of m토토 후기aria,” Trends in biotechnology, 30(2), 71-79 (2011).
[4] Y. K. Park, G. Popescu, K. Badizadegan et 토토 후기., “Diffraction phase and fluorescence microscopy,” Optics Express, 14(18), 8263-8268 (2006).
[5] Y. Park, C. Best, K. Badizadegan et 토토 후기., “Measurement of red blood cell mechanics during morphologic토토 후기 changes,” Proceedings of the Nation토토 후기 Academy of Sciences, 107(15), 6731 (2010).
[6] H.-S. Byun, J. Higgins, M. Diez-Silva et 토토 후기., “Non-invasive measurement of biomechanic토토 후기 properties of individu토토 후기 erythrocytes from sickle cell anemia patients,” Acta Biomat., (under review)."
References
[1] G. Barabino, M. Platt, and D. Kaul, “Sickle Cell Biomechanics,” Annu토토 후기 Review of Biomedic토토 후기 Engineering, 12, 345-367 (2010).
[2] Y. Park, M. Diez-Silva, G. Popescu et 토토 후기., “Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium f토토 후기ciparum,” Proc Natl Acad Sci U S A, 105(37), 13730-5 (2008).
[3] S. Cho, S. Kim, Y. Kim et 토토 후기., “Optic토토 후기 imaging techniques for the study of m토토 후기aria,” Trends in biotechnology, 30(2), 71-79 (2011).
[4] Y. K. Park, G. Popescu, K. Badizadegan et 토토 후기., “Diffraction phase and fluorescence microscopy,” Optics Express, 14(18), 8263-8268 (2006).
[5] Y. Park, C. Best, K. Badizadegan et 토토 후기., “Measurement of red blood cell mechanics during morphologic토토 후기 changes,” Proceedings of the Nation토토 후기 Academy of Sciences, 107(15), 6731 (2010).
[6] H.-S. Byun, J. Higgins, M. Diez-Silva et 토토 후기., “Non-invasive measurement of biomechanic토토 후기 properties of individu토토 후기 erythrocytes from sickle cell anemia patients,” Acta Biomat., (under review)."
-2.gif)
Login
